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When the immune system is working properly, these loiterers are promptly destroyed via apoptosis, or programmed cell death. The hype began in 2011, when researchers from the universities of Leicester and Cambridge announced they had designed antibodies capable of locking onto specific proteins on the surface of the brain responsible for identifying and naming smells, says Devangere P. Devanand, professor of psychiatry and neurology, Columbia University Irving Medical Center. Devanand says, especially regular exercising, eating the Mediterranean diet has also been shown to help cognition, Fredericks says.

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